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What is Shingrix?

Shingrix is a recombinant vaccine designed to prevent shingles (herpes zoster) and its complications, such as postherpetic neuralgia (PHN).

  • Adults aged 50 and older: Recommended to prevent shingles and related complications.
  • Immunocompromised individuals aged 18 and older: Approved to provide protection for those with weakened immune systems.

Shingrix is given in two doses:

  • First dose: Initial vaccination.
  • Second dose: Administered 2 to 6 months after the first dose.


Clinical studies indicate that Shingrix is over 90% effective in preventing shingles and its complications.

Common side effects, typically mild to moderate in intensity, include:

  • Pain, redness, and swelling at the injection site
  • Muscle pain
  • Fatigue
  • Headache
  • Fever

These side effects generally resolve within a few days.

  • Individuals with a history of severe allergic reaction to any component of the vaccine.
  • Those who have an active shingles infection.
  • People with a fever of 38.5°C (101.3°F) or higher should wait until they recover before getting vaccinated.

Current data suggests that Shingrix provides strong protection against shingles for at least four years. Ongoing studies are evaluating the long-term efficacy of the vaccine.

Yes, Shingrix is approved and recommended for immunocompromised individuals aged 18 and older. Clinical trials have shown it to be safe and effective in this population.

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