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What is the hepatitis B vaccine?

The hepatitis B vaccine is a safe and effective vaccine designed to protect against hepatitis B virus (HBV) infection. It stimulates the immune system to produce antibodies against the virus, thereby preventing the disease.

According to NHS and Green Book guidelines, the vaccine is recommended for:

  • Infants as part of their routine childhood immunizations.
  • Healthcare workers and others at high risk of exposure to HBV.
  • Individuals with certain medical conditions, such as chronic kidney disease or diabetes.
  • People at risk due to their lifestyle, including those with multiple sexual partners or those who inject drugs.


The hepatitis B vaccine is administered via an injection into the upper arm. For infants and children, the vaccine is typically given as part of a combination vaccine or separately as recommended in the vaccination schedule.

The standard schedule for hepatitis B vaccination includes three doses:

  • The first dose is given at birth (or as soon as possible afterward if missed).
  • The second dose is given 1-2 months after the first dose.
  • The third dose is given 6-12 months after the first dose.
  • For high-risk groups, additional doses might be recommended based on individual risk factors.


Common side effects are mild and may include soreness at the injection site, mild fever, or fatigue. Serious side effects are rare. If you experience severe allergic reactions or other unusual symptoms, contact a healthcare provider immediately.

The hepatitis B vaccine is highly effective, with a success rate of more than 90% in preventing HBV infection when the full vaccination course is completed. It provides long-term protection, often for life, after the full series of doses.

Routine booster doses are generally not required for those who have completed the initial vaccination series and are at low risk. However, certain high-risk individuals might need periodic testing and possibly booster doses based on their risk and immune response.

If a dose is missed, consult a healthcare provider to determine the best course of action. Missing a dose may require adjusting the schedule to ensure full vaccination coverage.

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